CRISPR Engineering of CAR T Cells to Enhance Efficacy in Solid Tumours

FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Jack D Chan, Christina M Scheffler, Isabelle Munoz, Kevin Sek, Joel N Lee, Yu-Kuan Huang, Kah Min Yap, Nicole YL Saw, Jasmine Li, Amanda XY Chen, Cheok Weng Chan, Emily B Derrick, Kirsten L Todd, Junming Tong, Phoebe A Dunbar, Jiawen Li, Thang X Hoang, Maria N de Menezes, Emma V Petley, Joelle S Kim

2024-01-01

Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of haematological malignancies such as acute lymphobl..